Genes that mediate breast cancer metastasis to lung

Article

关键词: EXPRESSION PROFILES;    TUMOR PROGRESSION;    METALLOPROTEINASES;    SIGNATURE;    MOLECULES;    CARCINOMA;    PROTEINS;    SURVIVAL;    NETWORK;    GROWTH;   

DOI  :  10.1038/nature03799

来源: SCIE

【 摘 要 】

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

【 授权许可】

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