Enhancing the potential of enantioselective organocatalysis with light

Review

关键词: 2+2 PHOTOCYCLOADDITION REACTIONS;    ALPHA-ALKYLATION;    PHOTOREDOX CATALYSIS;    BRONSTED ACID;    PHOTOCHEMICAL ACTIVITY;    ASYMMETRIC CATALYSIS;    ORGANIC CATALYSIS;    ALDEHYDES;    CARBON;    BENZYLATION;   

DOI  :  10.1038/nature25175

来源: SCIE

【 摘 要 】

Organocatalysis-catalysis mediated by small chiral organic molecules-is a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previously inaccessible reaction pathways, thereby creating new synthetic opportunities. Here we describe the historical context, scientific reasoning and landmark discoveries that were essential in expanding the functions of organocatalysis to include one-electronmediated chemistry and excited-state reactivity.

【 授权许可】

Free