PIWI proteins and PIWI-interacting RNAs in the soma

Review

关键词: PROGRAMMED DNA ELIMINATION;    PRIMARY PIRNA BIOGENESIS;    CELL SELF-RENEWAL;    GERMLINE STEM-CELLS;    TUMOR-RELATED DEATH;    DROSOPHILA-MELANOGASTER;    GENOME REARRANGEMENT;    HIWI GENE;    MORPHOLOGICAL EVOLUTION;    PHENOTYPIC VARIATION;   

DOI  :  10.1038/nature12987

来源: SCIE

【 摘 要 】

The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated dimension of biology. The PIWI-piRNA pathway has been commonly perceived as germline-specific, even though the somatic function of PIWI proteins was documented when they were first discovered. Recent studies have begun to re-explore this pathway in somatic cells in diverse organisms, particularly lower eukaryotes. These studies have illustrated the multifaceted somatic functions of the pathway not only in transposon silencing but also in genome rearrangement and epigenetic programming, with biological roles in stem-cell function, whole-body regeneration, memory and possibly cancer.

【 授权许可】

Free