Pharmacogenomics in the clinic

Review

关键词: ACUTE LYMPHOBLASTIC-LEUKEMIA;    IMPLEMENTATION CONSORTIUM GUIDELINES;    ELECTRONIC MEDICAL-RECORDS;    ADVERSE DRUG-REACTIONS;    PERSONALIZED MEDICINE;    GENOMIC MEDICINE;    RESEARCH NETWORK;    PREEMPTIVE PHARMACOGENOMICS;    MERCAPTOPURINE INTOLERANCE;    COMPANION DIAGNOSTICS;   

DOI  :  10.1038/nature15817

来源: SCIE

【 摘 要 】

After decades of discovery, inherited variations have been identified in approximately 20 genes that affect about 80 medications and are actionable in the clinic. And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a cornerstone for precision medicine.

【 授权许可】

Free