The genome sequence of the plant pathogen Xylella fastidiosa

Article

关键词: CITRUS VARIEGATED CHLOROSIS;    VIRULENCE FACTORS;    SWEET ORANGE;    HAEMOPHILUS-INFLUENZAE;    DICHELOBACTER-NODOSUS;    LIMITED BACTERIUM;    ESCHERICHIA-COLI;    RTX TOXINS;    IDENTIFICATION;    SECRETION;   

DOI  :  10.1038/35018003

来源: SCIE

【 摘 要 】

Xylella fastidiosa is a fastidious, xylem-limited bacterium that causes a range of economically important plant diseases. Here we report the complete genome sequence of X. fastidiosa clone 9a5c, which causes citrus variegated chlorosis-a serious disease of orange trees. The genome comprises a 52.7% GC-rich 2,679,305-base-pair (bp) circular chromosome and two plasmids of 51,158 bp and 1,285 bp. We can assign putative functions to 47% of the 2,904 predicted coding regions. Efficient metabolic functions are predicted, with sugars as the principal energy and carbon source, supporting existence in the nutrient-poor xylem sap. The mechanisms associated with pathogenicity and virulence involve toxins, antibiotics and ion sequestration systems, as well as bacterium-bacterium and bacterium-host interactions mediated by a range of proteins. Orthologues of some of these proteins have only been identified in animal and human pathogens; their presence in X. fastidiosa indicates that the molecular basis for bacterial pathogenicity is both conserved and independent of host. At least 83 genes are bacteriophage-derived and include virulence-associated genes from other bacteria, providing direct evidence of phage-mediated horizontal gene transfer.

【 授权许可】

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