Cellular immune responses to HIV

Review

关键词: CYTOTOXIC T-LYMPHOCYTES;    IMMUNODEFICIENCY-VIRUS TYPE-1;    ACTIVE ANTIRETROVIRAL THERAPY;    FAS LIGAND EXPRESSION;    IN-VIVO;    PERIPHERAL-BLOOD;    INTERFERON-GAMMA;    BETA-CHEMOKINES;    ESCAPE VARIANTS;    INFECTED-CELLS;   

DOI  :  10.1038/35073658

来源: SCIE

【 摘 要 】

The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4(+) T cells and the uninfected CD8(+) T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.

【 授权许可】

Free