Rethinking schizophrenia

Article

关键词: CHILDHOOD-ONSET SCHIZOPHRENIA;    ULTRA-HIGH RISK;    FOLLOW-UP;    OBSTETRIC COMPLICATIONS;    ADULT SCHIZOPHRENIA;    PSYCHOTIC DISORDERS;    PRENATAL EXPOSURE;    BRAIN-DEVELOPMENT;    DEFICITS;    GENES;   

DOI  :  10.1038/nature09552

来源: SCIE

【 摘 要 】

How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently disabling mental disorder that affects about one per cent of the world's population. After a century of studying schizophrenia, the cause of the disorder remains unknown. Treatments, especially pharmacological treatments, have been in wide use for nearly half a century, yet there is little evidence that these treatments have substantially improved outcomes for most people with schizophrenia. These current unsatisfactory outcomes may change as we approach schizophrenia as a neurodevelopmental disorder with psychosis as a late, potentially preventable stage of the illness. This 'rethinking' of schizophrenia as a neurodevelopmental disorder, which is profoundly different from the way we have seen this illness for the past century, yields new hope for prevention and cure over the next two decades.

【 授权许可】

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