MULTIPLE-MODES OF ENGRAILED REGULATION IN THE PROGRESSION TOWARDS CELL FATE DETERMINATION

Article

关键词: SEGMENT-POLARITY GENE;    DROSOPHILA EMBRYOS;    DEVELOPMENTAL COMPARTMENTALIZATION;    AUTO-REGULATION;    WINGLESS GENE;    EXPRESSION;    LOCALIZATION;    TRANSCRIPTS;    PROTEIN;    LOCUS;   

DOI  :  10.1038/352404a0

来源: SCIE

【 摘 要 】

The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed- independent mode of maintenance.

【 授权许可】

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