Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Article

关键词: MEIOTIC CHROMOSOME SYNAPSIS;    CANCER SUSCEPTIBILITY GENE;    FAMILIAL BREAST;    OVARIAN-CANCER;    RECA HOMOLOGS;    PROTEIN;    REPAIR;    MOUSE;    YEAST;    RECOMBINATION;   

DOI  :  10.1038/386804a0

来源: SCIE

【 摘 要 】

Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2.

【 授权许可】

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