Challenges in the development of an HIV-1 vaccine

Review

关键词: IMMUNODEFICIENCY-VIRUS TYPE-1;    T-CELL RESPONSES;    RETROVIRUSES HTLV-III;    PLASMID DNA VACCINE;    SIMIAN IMMUNODEFICIENCY;    IMMUNE-RESPONSES;    DISEASE PROGRESSION;    VIRAL LOAD;    IMMUNOGENICITY EVALUATION;    MONOCLONAL-ANTIBODIES;   

DOI  :  10.1038/nature07352

来源: SCIE

【 摘 要 】

The development of a safe and effective human immunodeficiency virus (HIV)-1 vaccine is a critically important global health priority. Despite recent advances in our understanding of HIV-1 pathogenesis and immunology, however, major scientific obstacles remain. Prototype HIV-1 vaccine candidates aimed at eliciting humoral and cellular immune responses have so far failed to protect against HIV- 1 infection or to reduce viral loads after infection in clinical efficacy studies. A renewed and coordinated commitment to basic discovery research, preclinical studies and clinical trials will therefore be required to overcome the hurdles currently facing the field. Here I review key challenges and future prospects in the quest to develop a prophylactic HIV- 1 vaccine.

【 授权许可】

Free