ALLELE-SPECIFIC MOTIFS REVEALED BY SEQUENCING OF SELF-PEPTIDES ELUTED FROM MHC MOLECULES

Article

关键词: TOXIC LYMPHOCYTES-T;    MAJOR HISTOCOMPATIBILITY COMPLEX;    CLASS-I MOLECULES;    SYNTHETIC PEPTIDES;    CIRCUMSPOROZOITE PROTEIN;    INFLUENZA NUCLEOPROTEIN;    MONOCLONAL-ANTIBODIES;    IMMUNOGENIC PEPTIDES;    CELL RECOGNITION;    FINE SPECIFICITY;   

DOI  :  10.1038/351290a0

来源: SCIE

【 摘 要 】

The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information about the contents of MHC grooves is now provided. Moreover, each MHC class I allele has its individual rules to which peptides presented in the grove adhere.

【 授权许可】

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