Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins

Article

关键词: SCF UBIQUITIN-LIGASE;    ARABIDOPSIS-THALIANA;    RESPONSE ELEMENTS;    GENE;    YEAST;    TRANSCRIPTION;    PATHWAY;    FAMILY;    NEDD8;    RUB1;   

DOI  :  10.1038/35104500

来源: SCIE

【 摘 要 】

The plant hormone auxin is central in many aspects of plant development. Previous studies have implicated the ubiquitin-ligase SCFTIR1 and the AUX/IAA proteins in auxin response. Dominant mutations in several AUX/IAA genes confer pleiotropic auxin-related phenotypes, whereas recessive mutations affecting the function of SCFTIR1 decrease auxin response. Here we show that SCFTIR1 is required for AUX/IAA degradation. We demonstrate that SCFTIR1 interacts with AXR2/IAA7 and AXR3/IAA17, and that domain II of these proteins is necessary and sufficient for this interaction. Further, auxin stimulates binding of SCFTIR1 to the AUX/IAA proteins, and their degradation. Because domain II is conserved in nearly all AUX/IAA proteins in Arabidopsis, we propose that auxin promotes the degradation of this large family of transcriptional regulators, leading to diverse downstream effects.

【 授权许可】

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