A microRNA polycistron as a potential human oncogene

Article

关键词: CAENORHABDITIS-ELEGANS;    DEVELOPMENTAL SWITCH;    IN-VIVO;    GENE;    RNA;    SUPPRESSION;    EXPRESSION;    LYMPHOMA;    ENCODES;    TARGET;   

DOI  :  10.1038/nature03552

来源: SCIE

【 摘 要 】

To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, noncoding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas(1). Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir- 17 - 92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir- 17 - 92 cluster as a potential human oncogene.

【 授权许可】

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