Tumour heterogeneity and cancer cell plasticity

Review

关键词: ACUTE MYELOID-LEUKEMIA;    CHRONIC MYELOGENOUS LEUKEMIA;    HEMATOPOIETIC STEM-CELLS;    INITIATING CELLS;    BCR-ABL;    LYMPHOBLASTIC-LEUKEMIA;    CLONAL EVOLUTION;    MELANOMA-CELLS;    PHENOTYPIC HETEROGENEITY;    PROPAGATING CELLS;   

DOI  :  10.1038/nature12624

来源: SCIE

【 摘 要 】

Phenotypic and functional heterogeneity arise among cancer cells within the same tumour as a consequence of genetic change, environmental differences and reversible changes in cell properties. Some cancers also contain a hierarchy in which tumorigenic cancer stem cells differentiate into non-tumorigenic progeny. However, it remains unclear what fraction of cancers follow the stem-cell model and what clinical behaviours the model explains. Studies using lineage tracing and deep sequencing could have implications for the cancer stem-cell model and may help to determine the extent to which it accounts for therapy resistance and disease progression.

【 授权许可】

Free