Quality control in the endoplasmic reticulum protein factory

Article

关键词: SECRETORY PATHWAY;    MOLECULAR CHAPERONES;    DISULFIDE BONDS;    ER STRESS;    CELLS;    NEURODEGENERATION;    AGGREGATION;    METABOLISM;    RECEPTOR;    CYTOSOL;   

DOI  :  10.1038/nature02262

来源: SCIE

【 摘 要 】

The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.

【 授权许可】

Free