Exploring biology with small organic molecules

Article

关键词: DIVERSITY-ORIENTED SYNTHESIS;    REFLECTOMETRIC INTERFERENCE SPECTROSCOPY;    FOCUSED COMBINATORIAL LIBRARIES;    PROTEIN-PROTEIN INTERACTIONS;    DRUG DISCOVERY;    CHEMICAL GENETICS;    RNA INTERFERENCE;    TARGET IDENTIFICATION;    GLOBAL ANALYSIS;    SOLID-PHASE;   

DOI  :  10.1038/nature03196

来源: SCIE

【 摘 要 】

Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore 'biological-activity space'. Such strategies involve analysing both protein binding of, and phenotypic responses to, small organic molecules. The mapping of biological-activity space using small molecules is akin to mapping the stars - uncharted territory is explored using a system of coordinates that describes where each new feature lies.

【 授权许可】

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