Autophagy fights disease through cellular self-digestion

Review

关键词: CHAPERONE-MEDIATED AUTOPHAGY;    INCLUSION-BODY FORMATION;    REGULATES AUTOPHAGY;    ALPHA-SYNUCLEIN;    DEGRADATION;    BECLIN-1;    ROLES;    DEATH;    CELLS;    NEURODEGENERATION;   

DOI  :  10.1038/nature06639

来源: SCIE

【 摘 要 】

Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.

【 授权许可】

Free