Stem cells and interspecies chimaeras

Review

关键词: NEURAL CREST CELLS;    HUMAN-NONHUMAN CHIMERAS;    IN-VIVO;    NAIVE PLURIPOTENCY;    GROUND-STATE;    MOUSE;    EPIBLAST;    LINES;    GENERATION;    RAT;   

DOI  :  10.1038/nature20573

来源: SCIE

【 摘 要 】

Chimaeras are both monsters of the ancient imagination and a long-established research tool. Recent advances, particularly those dealing with the identification and generation of various kinds of stem cells, have broadened the repertoire and utility of mammalian interspecies chimaeras and carved out new paths towards understanding fundamental biology as well as potential clinical applications.

【 授权许可】

Free