DISRUPTION OF THE CNTF GENE RESULTS IN MOTOR-NEURON DEGENERATION

Article

关键词: CILIARY NEUROTROPHIC FACTOR;    TYPE-2 ASTROCYTE DEVELOPMENT;    CHOLINERGIC DIFFERENTIATION;    NEURONOTROPHIC FACTOR;    REGIONAL DISTRIBUTION;    FACTOR PREVENTS;    MESSENGER-RNA;    GROWTH-FACTOR;    SPINAL-CORD;    RAT-BRAIN;   

DOI  :  10.1038/365027a0

来源: SCIE

【 摘 要 】

CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.

【 授权许可】

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