期刊论文详细信息
DISRUPTION OF THE CNTF GENE RESULTS IN MOTOR-NEURON DEGENERATION | |
Article | |
关键词: CILIARY NEUROTROPHIC FACTOR; TYPE-2 ASTROCYTE DEVELOPMENT; CHOLINERGIC DIFFERENTIATION; NEURONOTROPHIC FACTOR; REGIONAL DISTRIBUTION; FACTOR PREVENTS; MESSENGER-RNA; GROWTH-FACTOR; SPINAL-CORD; RAT-BRAIN; | |
DOI : 10.1038/365027a0 | |
来源: SCIE |
【 摘 要 】
CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.
【 授权许可】
Free