Molecular machines governing exocytosis of synaptic vesicles

Review

关键词: N-TERMINAL PEPTIDE;    SNARE COMPLEX;    MEMBRANE-FUSION;    3-DIMENSIONAL STRUCTURE;    SINGLE-MOLECULE;    CA2+ SENSOR;    CONFORMATIONAL SWITCH;    CRYSTAL-STRUCTURE;    SYNAPTOTAGMIN;    SYNTAXIN;   

DOI  :  10.1038/nature11320

来源: SCIE

【 摘 要 】

Calcium-dependent exocytosis of synaptic vesicles mediates the release of neurotransmitters. Important proteins in this process have been identified such as the SNAREs, synaptotagmins, complexins, Munc18 and Munc13. Structural and functional studies have yielded a wealth of information about the physiological role of these proteins. However, it has been surprisingly difficult to arrive at a unified picture of the molecular sequence of events from vesicle docking to calcium-triggered membrane fusion. Using mainly a biochemical and biophysical perspective, we briefly survey the molecular mechanisms in an attempt to functionally integrate the key proteins into the emerging picture of the neuronal fusion machine.

【 授权许可】

Free