NEW USE OF BCG FOR RECOMBINANT VACCINES

Article

关键词: ESCHERICHIA-COLI;    STRESS PROTEINS;    LYMPHOCYTES-T;    INVIVO;    MYCOBACTERIA;    EXPRESSION;    SEQUENCE;    TUBERCULOSIS;    CLONING;    OPERON;   

DOI  :  10.1038/351456a0

来源: SCIE

【 摘 要 】

BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.

【 授权许可】

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