Pervasive roles of microRNAs in cardiovascular biology

Review

关键词: NEOINTIMAL LESION FORMATION;    CONGENITAL HEART-DISEASE;    MUSCLE-SPECIFIC MICRORNA;    CORONARY-ARTERY-DISEASE;    EMBRYONIC STEM-CELLS;    CHANNEL GENES HCN2;    CARDIAC-HYPERTROPHY;    VASCULAR INTEGRITY;    FAILURE PATIENTS;    DOWN-REGULATION;   

DOI  :  10.1038/nature09783

来源: SCIE

【 摘 要 】

First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wide-ranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.

【 授权许可】

Free