The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Article

关键词: NONALCOHOLIC FATTY LIVER;    DE-NOVO LIPOGENESIS;    C3 GENE VARIANTS;    SKELETAL-MUSCLE;    PYRUVATE-CARBOXYLASE;    CELLULAR MECHANISMS;    ENERGY-EXPENDITURE;    METABOLIC SYNDROME;    CGI-58 KNOCKDOWN;    WEIGHT-REDUCTION;   

DOI  :  10.1038/nature13478

来源: SCIE

【 摘 要 】

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase C epsilon in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.

【 授权许可】

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