Functionalized olefin cross-coupling to construct carbon-carbon bonds

Article

关键词: CONJUGATE ADDITION;    UNACTIVATED OLEFINS;    TERTIARY ALCOHOLS;    HYDROGENATION;    REAGENTS;    ESTERS;    PHENYLSILANE;    CHEMISTRY;    MECHANISM;    RADICALS;   

DOI  :  10.1038/nature14006

来源: SCIE

【 摘 要 】

Carbon-carbon (C-C) bonds form the backbone of many important molecules, including polymers, dyes and pharmaceutical agents. The development of new methods to create these essential connections in a rapid and practical fashion has been the focus of numerous organic chemists. This endeavour relies heavily on the ability to form C-C bonds in the presence of sensitive functional groups and congested structural environments. Here we report a chemical transformation that allows the facile construction of highly substituted and uniquely functionalized C-C bonds. Using a simple iron catalyst, an inexpensive silane and a benign solvent under ambient atmosphere, heteroatom-substituted olefins are easily reacted with electron-deficient olefins to create molecular architectures that were previously difficult or impossible to access. More than 60 examples are presented with a wide array of substrates, demonstrating the chemoselectivity and mildness of this simple reaction.

【 授权许可】

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