Regulation of cap-dependent translation by eIF4E inhibitory proteins

Article

关键词: MESSENGER-RNA TRANSLATION;    TERM SYNAPTIC PLASTICITY;    BINDING-PROTEIN;    CYTOPLASMIC POLYADENYLATION;    DROSOPHILA CUP;    INITIATION;    PHOSPHORYLATION;    COMPLEX;    RECRUITMENT;    REPRESSION;   

DOI  :  10.1038/nature03205

来源: SCIE

【 摘 要 】

Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 50 ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.

【 授权许可】

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