期刊论文详细信息
Focused specificity of intestinal T(H)17 cells towards commensal bacterial antigens
Article
关键词: SEGMENTED FILAMENTOUS BACTERIA;    T-CELLS;    MICROBIOTA;    TH17;    INDUCTION;    DIFFERENTIATION;    IDENTIFICATION;    EXPRESSION;    MATURATION;    PREDICTION;   
DOI  :  10.1038/nature13279
来源: SCIE
【 摘 要 】

T-helper-17 (T(H)17) cells have critical roles in mucosal defence and in autoimmune disease pathogenesis(1-3). They are most abundant in the small intestine lamina propria, where their presence requires colonization of mice with microbiota(4-7). Segmented filamentous bacteria (SFB) are sufficient to induce T(H)17 cells and to promote T(H)17-dependent autoimmune disease in animal models(8-14). However, the specificity of T(H)17 cells, the mechanism of their induction by distinct bacteria, and the means by which they foster tissue-specific inflammation remain unknown. Here we show that the T-cell antigen receptor (TCR) repertoire of intestinal T(H)17 cells in SFB-colonized mice has minimal overlap with that of other intestinal CD4(+) T cells and that most T(H)17 cells, but not other T cells, recognize antigens encoded by SFB. T cells with antigen receptors specific for SFB-encoded peptides differentiated into ROR gamma t-expressing T(H)17 cells, even if SFB-colonized mice also harboured a strong T(H)1 cell inducer, Listeria monocytogenes, in their intestine. The match of T-cell effector function with antigen specificity is thus determined by the type of bacteria that produce the antigen. These findings have significant implications for understanding how commensal microbiota contribute to organ-specific autoimmunity and for developing novel mucosal vaccines.

【 授权许可】

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