Chromatin dynamics during cellular reprogramming

Review

关键词: PLURIPOTENT STEM-CELLS;    MOUSE SOMATIC-CELLS;    GROUND-STATE PLURIPOTENCY;    PRIMORDIAL GERM-CELLS;    DNA DEMETHYLATION;    HISTONE VARIANTS;    SELF-RENEWAL;    C-MYC;    TRANSCRIPTION FACTORS;    LINEAGE SPECIFIERS;   

DOI  :  10.1038/nature12749

来源: SCIE

【 摘 要 】

Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it provides a unique assay to study the interplay between transcription factors and chromatin structure. Here, we review the latest insights into chromatin dynamics that are inherent to induced pluripotency. Moreover, we compare and contrast these events with other physiological and pathological processes that involve changes in chromatin and cell state, including germ cell maturation and tumorigenesis. We propose that an integrated view of these seemingly diverse processes could provide mechanistic insights into cell fate transitions in general and might lead to new approaches in regenerative medicine and cancer treatment.

【 授权许可】

Free