Increased bone formation in osteocalcin-deficient mice

Article

关键词: MATRIX GLA PROTEIN;    RAT BONE;    MOUSE;    EXPRESSION;    GENE;    INTERLEUKIN-6;    OSTEOPONTIN;    OSTEOCLASTS;    MARKER;    FORM;   

DOI  :  10.1038/382448a0

来源: SCIE

【 摘 要 】

VERTEBRATES constantly remodel bone. The resorption of preexisting bone by osteoclasts and the formation of new hone by osteoblasts is strictly coordinated to maintain bone mass within defined limits. A fen molecular determinants of bone remodelling that affect osteoclast activity(1-3) have been characterized, bot the molecular determinants of osteoblast activity are unknown. To investigate the role of osteocalcin, the most abundant osteoblast-specific non-collagenous protein(4) we have generated osteocalcin-deficient mice. These mice develop a phenotype marked by higher bone mass and bones of Improved functional quality. Histomorphometric studies done before and after ovariectomy showed that the absence of osteocalcin leads to an increase in bone formation without impairing bone resorption. To our knowledge, this study provides the first evidence that osteocalcin is a determinant of bone formation.

【 授权许可】

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