Catalytic enantioselective synthesis of quaternary carbon stereocentres

Review

关键词: ASYMMETRIC CONJUGATE ADDITION;    SUBSTITUTED CYCLIC ENONES;    ARYL ALUMINUM REAGENTS;    DIELS-ALDER REACTIONS;    TRISUBSTITUTED ENONES;    ALLYLIC ALKYLATION;    STEREOGENIC CENTERS;    INTRAMOLECULAR ARYLCYANATION;    POLYENE CYCLIZATION;    OLEFIN METATHESIS;   

DOI  :  10.1038/nature14007

来源: SCIE

【 摘 要 】

Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single stereoisomers of this important structural motif. Here we discuss the many catalytic enantioselective reactions developed during the past decade for the synthesis of single stereoisomers of such organic molecules. This progress now makes it possible to incorporate quaternary stereocentres selectively in many organic molecules that are useful in medicine, agriculture and potentially other areas such as flavouring, fragrances and materials.

【 授权许可】

Free