Nutrient-sensing mechanisms and pathways

Review

关键词: ACTIVATING PROTEIN COMPLEX;    GCN2 EIF2-ALPHA KINASE;    AMINO-ACID DEPRIVATION;    UNCHARGED TRANSFER-RNA;    SWEET TASTE RECEPTORS;    ADIPOSE-SPECIFIC GENE;    RAG GTPASES;    INSULIN-RESISTANCE;    TUMOR-SUPPRESSOR;    SCAP PROTEIN;   

DOI  :  10.1038/nature14190

来源: SCIE

【 摘 要 】

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels of sugars, amino acids, lipids and surrogate metabolites are integrated and coordinated at the organismal level through hormonal signals. During food abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of internal stores through autophagy. Nutrient-sensing pathways are commonly deregulated in human metabolic diseases.

【 授权许可】

Free