Diet-microbiota interactions as moderators of human metabolism

Review

关键词: CARBOHYDRATE-ACTIVE ENZYMES;    PROTEIN-COUPLED RECEPTOR;    GUT MICROBIOTA;    INTESTINAL MICROBIOTA;    INSULIN-RESISTANCE;    ENERGY-METABOLISM;    INDUCED OBESITY;    T-CELLS;    BARIATRIC SURGERY;    FATTY-ACIDS;   

DOI  :  10.1038/nature18846

来源: SCIE

【 摘 要 】

It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.

【 授权许可】

Free