A comprehensive transcriptional map of primate brain development

Article

关键词: HUMAN PREFRONTAL CORTEX;    HUMAN CEREBRAL-CORTEX;    ADULT HUMAN BRAIN;    GENE-EXPRESSION;    RHESUS-MONKEY;    VISUAL-CORTEX;    SYNAPTIC DEVELOPMENT;    POSITIVE SELECTION;    MOLECULAR PATHWAYS;    RNA-SEQ;   

DOI  :  10.1038/nature18637

来源: SCIE

【 摘 要 】

The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons. Cortical layers and areas acquire adult-like molecular profiles surprisingly late in postnatal development. Disparate cell populations exhibit distinct developmental timing of gene expression, but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. Human developmental expression trajectories are more similar to monkey than rodent, although approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny compared to monkey.

【 授权许可】

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