The dietary sweetener sucralose is a negative modulator of T cell-mediated responses

Article

关键词: TASTE RECEPTORS;    ACTIVATION;    ASSOCIATION;    RESOLUTION;    T1R3;   

DOI  :  10.1038/s41586-023-05801-6

来源: SCIE

【 摘 要 】

Artificial sweeteners are used as calorie-free sugar substitutes in many food products and their consumption has increased substantially over the past years(1). Although generally regarded as safe, some concerns have been raised about the long-term safety of the consumption of certain sweeteners(2-5). In this study, we show that the intake of high doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation. Mechanistically, sucralose affects the membrane order of T cells, accompanied by a reduced efficiency of T cell receptor signalling and intracellular calcium mobilization. Mice given sucralose show decreased CD8(+) T cell antigen-specific responses in subcutaneous cancer models and bacterial infection models, and reduced T cell function in models of T cell-mediated autoimmunity. Overall, these findings suggest that a high intake of sucralose can dampen T cell-mediated responses, an effect that could be used in therapy to mitigate T cell-dependent autoimmune disorders.

【 授权许可】

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