Selecting and maintaining a diverse T-cell repertoire

Review

关键词: SINGLE MHC/PEPTIDE LIGAND;    ANTIGEN RECEPTOR GENES;    CLASS-II MOLECULES;    ATHYMIC NUDE RATS;    POSITIVE SELECTION;    SELF-PEPTIDES;    HISTOCOMPATIBILITY ANTIGEN;    HOMEOSTATIC REGULATION;    THYMOCYTE DEVELOPMENT;    LYMPHOID HOMEOSTASIS;   

DOI  :  10.1038/35005508

来源: SCIE

【 摘 要 】

To provide a T-cell population that will respond promptly to foreign antigen, the immune system looks inward, using the variety of self-antigens to select and maintain a diverse repertoire of receptors. A protective Immune system must include a T-lymphocyte population that is poised to respond to foreign antigenic peptides presented by self-major histocompatibility complex molecules. As the organism cannot predict the precise pathogen-derived antigens that will he encountered, the system uses the diverse array of self-peptides bound to self-major histocompatibility complex molecules, not only to select a receptor repertoire in the thymus, but also to keep naive T cells alive and 'ready for action' in the periphery.

【 授权许可】

Free