Selecting and maintaining a diverse T-cell repertoire | |
Review | |
关键词: SINGLE MHC/PEPTIDE LIGAND; ANTIGEN RECEPTOR GENES; CLASS-II MOLECULES; ATHYMIC NUDE RATS; POSITIVE SELECTION; SELF-PEPTIDES; HISTOCOMPATIBILITY ANTIGEN; HOMEOSTATIC REGULATION; THYMOCYTE DEVELOPMENT; LYMPHOID HOMEOSTASIS; | |
DOI : 10.1038/35005508 | |
来源: SCIE |
【 摘 要 】
To provide a T-cell population that will respond promptly to foreign antigen, the immune system looks inward, using the variety of self-antigens to select and maintain a diverse repertoire of receptors. A protective Immune system must include a T-lymphocyte population that is poised to respond to foreign antigenic peptides presented by self-major histocompatibility complex molecules. As the organism cannot predict the precise pathogen-derived antigens that will he encountered, the system uses the diverse array of self-peptides bound to self-major histocompatibility complex molecules, not only to select a receptor repertoire in the thymus, but also to keep naive T cells alive and 'ready for action' in the periphery.
【 授权许可】
Free