Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

Article

关键词: RESPIRATORY SYNDROME CORONAVIRUS;    SARS-CORONAVIRUS;    GENOMIC CHARACTERIZATION;    BATS;    ORIGIN;    BETACORONAVIRUSES;    DIVERSITY;    CHINA;    ALPHACORONAVIRUSES;    IDENTIFICATION;   

DOI  :  10.1038/s41586-020-2169-0

来源: SCIE

【 摘 要 】

The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-2(1). This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection(2).Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manisjavanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.

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