The structure and function of G-protein-coupled receptors

Review

关键词: BETA-ADRENERGIC-RECEPTOR;    INTERNAL WATER-MOLECULES;    CONSERVED ASPARTIC-ACID;    CRYSTAL-STRUCTURE;    BETA(2)-ADRENERGIC RECEPTOR;    BOVINE RHODOPSIN;    DRUG DISCOVERY;    HELIX MOVEMENT;    BINDING-SITE;    IONIC LOCK;   

DOI  :  10.1038/nature08144

来源: SCIE

【 摘 要 】

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

【 授权许可】

Free