Ancient human genome sequence of an extinct Palaeo-Eskimo

Article

关键词: DNA;    POLYMORPHISMS;    DETERMINANT;    RESOLUTION;    COLOR;    GENE;   

DOI  :  10.1038/nature08835

来源: SCIE

【 摘 要 】

We report here the genome sequence of an ancient human. Obtained from similar to 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20X, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.

【 授权许可】

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