A spindle-independent cleavage furrow positioning pathway

Article

关键词: NONMUSCLE MYOSIN-II;    DROSOPHILA NEUROBLASTS;    ASYMMETRIC DIVISIONS;    CELL-DIVISION;    CORTICAL POLARITY;    CONTRACTILE RING;    PROTEIN COMPLEX;    ALPHA-I;    CYTOKINESIS;    ORIENTATION;   

DOI  :  10.1038/nature09334

来源: SCIE

【 摘 要 】

The mitotic spindle determines the cleavage furrow site during metazoan cell division(1,2), but whether other mechanisms exist remains unknown. Here we identify a spindle-independent mechanism for cleavage furrow positioning in Drosophila neuroblasts. We show that early and late furrow proteins (Pavarotti, Anillin, and Myosin) are localized to the neuroblast basal cortex at anaphase onset by a Pins cortical polarity pathway, and can induce a basally displaced furrow even in the complete absence of a mitotic spindle. Rotation or displacement of the spindle results in two furrows: an early polarity-induced basal furrow and a later spindle-induced furrow. This spindle-independent cleavage furrow mechanism may be relevant to other highly polarized mitotic cells, such as mammalian neural progenitors.

【 授权许可】

Free