Directional guidance of neuronal migration in the olfactory system by the protein Slit

Article

关键词: SUBVENTRICULAR ZONE CELLS;    NEURAL CREST MIGRATION;    FETAL MONKEY NEOCORTEX;    POLYSIALIC ACID;    NERVOUS-SYSTEM;    AXON GUIDANCE;    GENE ENCODES;    C-ELEGANS;    GLIA;    PRECURSORS;   

DOI  :  10.1038/22477

来源: SCIE

【 摘 要 】

Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.

【 授权许可】

Free