Small RNAs in transcriptional gene silencing and genome defence

Review

关键词: DOUBLE-STRANDED-RNA;    FISSION YEAST;    HISTONE H3;    C-ELEGANS;    DNA METHYLATION;    SIRNA PATHWAY;    CAENORHABDITIS-ELEGANS;    LYSINE-9 METHYLATION;    ARABIDOPSIS-THALIANA;    CHROMATIN-STRUCTURE;   

DOI  :  10.1038/nature07756

来源: SCIE

【 摘 要 】

Small RNA molecules of about 20 - 30 nucleotides have emerged as powerful regulators of gene expression and genome stability. Studies in fission yeast and multicellular organisms suggest that effector complexes, directed by small RNAs, target nascent chromatin- bound non- coding RNAs and recruit chromatin modifying complexes. Interactions between small RNAs and nascent non- coding transcripts thus reveal a new mechanism for targeting chromatin- modifying complexes to specific chromosome regions and suggest possibilities for how the resultant chromatin states may be inherited during the process of chromosome duplication.

【 授权许可】

Free