期刊论文详细信息
The contribution of bone to whole-organism physiology | |
Review | |
关键词: TRYPTOPHAN-HYDROXYLASE INHIBITORS; SYMPATHETIC-NERVOUS-SYSTEM; RECEPTOR-RELATED PROTEIN-5; TYROSINE-PHOSPHATASE 1B; ENERGY-METABOLISM; BODY-WEIGHT; INVOLUTIONAL OSTEOPOROSIS; POSTMENOPAUSAL WOMEN; SEROTONIN SYNTHESIS; GLUCOSE-METABOLISM; | |
DOI : 10.1038/nature10763 | |
来源: SCIE |
【 摘 要 】
The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
【 授权许可】
Free