The contribution of bone to whole-organism physiology

Review

关键词: TRYPTOPHAN-HYDROXYLASE INHIBITORS;    SYMPATHETIC-NERVOUS-SYSTEM;    RECEPTOR-RELATED PROTEIN-5;    TYROSINE-PHOSPHATASE 1B;    ENERGY-METABOLISM;    BODY-WEIGHT;    INVOLUTIONAL OSTEOPOROSIS;    POSTMENOPAUSAL WOMEN;    SEROTONIN SYNTHESIS;    GLUCOSE-METABOLISM;   

DOI  :  10.1038/nature10763

来源: SCIE

【 摘 要 】

The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.

【 授权许可】

Free