A multivalent PDZ-domain protein assembles signalling complexes in a g-protein-coupled cascade

Article

关键词: SIGNALING PROTEINS;    PTB DOMAIN;    DROSOPHILA;    TRANSDUCTION;    JUNCTIONS;    HOMOLOG;    SEPTATE;    KINASES;    MODULE;    GENE;   

DOI  :  10.1038/40805

来源: SCIE

【 摘 要 】

How are signalling molecules organized into different pathways within the same cell? In Drosophila, the inaD gene encodes a protein consisting of five PDZ domains which serves as a scaffold to assemble different components of the phototransduction cascade, including the principal fight-activated ion channels, the effector phospholipase C-beta and protein kinase C, Null inaD mutants have a dramatically reorganized subcellular distribution of signalling molecules, and a total loss of transduction complexes. Also, mutants defective in a single PDZ domain produce signalling complexes that lack the target protein and display corresponding defects in their physiology. A picture emerges of a highly organized unit of signalling, a 'transducisome', with PDZ domains functioning as key elements in the organization of transduction complexes in vivo.

【 授权许可】

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