An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

Article

关键词: SMALL INTERFERING RNAS;    CARTILAGE-HAIR-HYPOPLASIA;    HEPATITIS-C VIRUS;    HUMAN TELOMERASE;    CATALYTIC SUBUNIT;    HUMAN-CELLS;    GENETIC ELEMENTS;    MARROW FAILURE;    IMMORTAL CELLS;    MOUSE OOCYTES;   

DOI  :  10.1038/nature08283

来源: SCIE

【 摘 要 】

Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit ( TERT) contributes to cell physiology independently of its ability to elongate telomeres. Here we show that TERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilage-hair hypoplasia. Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double- stranded RNAs that can be processed into small interfering RNA in a Dicer ( also known as DICER1)-dependent manner. These observations identify a mammalian RdRP composed of TERT in complex with RMRP.

【 授权许可】

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