The microcosmos of cancer

Review

关键词: EPITHELIAL-MESENCHYMAL TRANSITION;    DOWN-REGULATION;    POSTTRANSCRIPTIONAL REGULATION;    MICRORNA EXPRESSION;    ACTIVATED MICRORNA;    TUMOR SUPPRESSORS;    RNA INTERFERENCE;    P53 NETWORK;    LUNG-CANCER;    MYC;   

DOI  :  10.1038/nature10888

来源: SCIE

【 摘 要 】

The discovery of microRNAs (miRNAs) almost two decades ago established a new paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have been linked to virtually all known physiological and pathological processes, including cancer. In the same way as certain key protein-coding genes, miRNAs can be deregulated in cancer, in which they can function as a group to mark differentiation states or individually as bona fide oncogenes or tumour suppressors. Importantly, miRNA biology can be harnessed experimentally to investigate cancer phenotypes or used therapeutically as a target for drugs or as the drug itself.

【 授权许可】

Free