T-FH-derived dopamine accelerates productive synapses in germinal centres

Article

关键词: FOLLICULAR HELPER-CELLS;    CATECHOLAMINE SYNTHESIS;    TYROSINE-HYDROXYLASE;    DENSE-CORE;    B-CELLS;    SELECTION;    NOREPINEPHRINE;    LYMPHOCYTE;    EXPRESSION;    MECHANISM;   

DOI  :  10.1038/nature23013

来源: SCIE

【 摘 要 】

Protective high-affinity antibody responses depend on competitive selection of B cells carrying somatically mutated B-cell receptors by follicular helper T (T-FH) cells in germinal centres. The rapid T-B-cell interactions that occur during this process are reminiscent of neural synaptic transmission pathways. Here we show that a proportion of human T-FH cells contain dense-core granules marked by chromogranin B, which are normally found in neuronal presynaptic terminals storing catecholamines such as dopamine. T-FH cells produce high amounts of dopamine and release it upon cognate interaction with B cells. Dopamine causes rapid translocation of intracellular ICOSL (inducible T-cell co-stimulator ligand, also known as ICOSLG) to the B-cell surface, which enhances accumulation of CD40L and chromogranin B granules at the human T-FH cell synapse and increases the synapse area. Mathematical modelling suggests that faster dopamine-induced T-B-cell interactions increase total germinal centre output and accelerate it by days. Delivery of neurotransmitters across the T-B-cell synapse may be advantageous in the face of infection.

【 授权许可】

Free