Progress in and promise of bacterial quorum sensing research

Review

关键词: PSEUDOMONAS-AERUGINOSA VIRULENCE;    HIGH-THROUGHPUT SCREEN;    SALMONELLA-TYPHIMURIUM;    SIGNALING MOLECULES;    ESCHERICHIA-COLI;    SOCIAL EVOLUTION;    STRUCTURAL IDENTIFICATION;    POLYMICROBIAL INFECTION;    PATHOGENIC BACTERIA;    GENETICAL EVOLUTION;   

DOI  :  10.1038/nature24624

来源: SCIE

【 摘 要 】

This Review highlights how we can build upon the relatively new and rapidly developing field of research into bacterial quorum sensing (QS). We now have a depth of knowledge about how bacteria use QS signals to communicate with each other and to coordinate their activities. In recent years there have been extraordinary advances in our understanding of the genetics, genomics, biochemistry, and signal diversity of QS. We are beginning to understand the connections between QS and bacterial sociality. This foundation places us at the beginning of a new era in which researchers will be able to work towards new medicines to treat devastating infectious diseases, and use bacteria to understand the biology of sociality.

【 授权许可】

Free