Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

Article

关键词: FIBER LTP;    2 FORMS;    PROTEIN;    RABPHILIN-3A;    FACILITATION;    SYNAPSINS;    NEURONS;   

DOI  :  10.1038/41574

来源: SCIE

【 摘 要 】

Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activation of the NMDA (N-methyl-D-aspartate) subtype of glutamate receptor, but LTP at hippocampal messy fibre synapses is independent of NMDA receptors and has a component that is induced and expressed presynaptically(1). It appears to be triggered by a rise in presynaptic Ca2+ (refs 2, 3), and requires the activation of protein kinase A(4-6), which leads to an increased release of glutamate(3,7-10). A great deal is known about the biochemical steps involved in the vesicular release of transmitter(11-13), but none of these steps has been directly implicated in long-term synaptic plasticity. Here we show that, although a variety of short-term plasticities are normal, LTP at messy fibre synapses is abolished in mice lacking the synaptic vesicle protein Rab3A.

【 授权许可】

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