Implications of chimaeric non-co-linear transcripts

Review

关键词: LONG NONCODING RNAS;    HUMAN GENOME;    SPLICED LEADER;    MESSENGER-RNAS;    FUNCTIONAL ELEMENTS;    PROSTATE-CANCER;    GENE FUSION;    SEQUENCE;    SITES;    IDENTIFICATION;   

DOI  :  10.1038/nature08452

来源: SCIE

【 摘 要 】

Deep sequencing of 'transcriptomes' - the collection of all RNA transcripts produced at a given time - from worms to humans reveals that some transcripts are composed of sequence segments that are not co-linear, with pieces of sequence coming from distant regions of DNA, even different chromosomes. Some of these 'chimaeric' transcripts are formed by genetic rearrangements, but others arise during post-transcriptional events. The 'trans-splicing' process in lower eukaryotes is well understood, but events in higher eukaryotes are not. The existence of such chimaeric RNAs has far-reaching implications for the potential information content of genomes and the way it is arranged.

【 授权许可】

Free