Specific cytoxic T cells eliminate cells producing neutralizing antibodies

Article

关键词: LYMPHOCYTIC CHORIOMENINGITIS VIRUS;    B-CELLS;    IMMUNE SUPPRESSION;    EXOGENOUS ANTIGEN;    MICE;    IMMUNOSUPPRESSION;    RESPONSES;    INFECTION;    COMPLEX;    AIDS;   

DOI  :  10.1038/382726a0

来源: SCIE

【 摘 要 】

IN medically important infections with cytopathic viruses, neutralizing antibodies are generated within 6-14 days. in contrast, such protective antibodies appear late (50-150 days) after infection with immunodeficiency virus (HIV) and hepatitis B virus (HBV) in humans, or lymphocytic choriomeningitis virus (LCMV) in mice(1-6). However, during these infections, non-neutralizing antibodies appear much earlier(2,6,7). It has been proposed that T cells suppress antibody responses generally and against viruses in vitro(6,8-10). Here we show that the suppression of neutralizing-antibody responses in LCMV infections in mice is due to selective infection of neutralizing-antibody producing B cells by this non-cytopathic virus, and their subsequent destruction by virus-specific cytotoxic T cells. Such specific B-cell elimination that leads to a delay in neutralizing-antibody production could help to establish persistent virus infections by non-cytopathic viruses.

【 授权许可】

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