The landscape of somatic copy-number alteration across human cancers

Article

关键词: ACUTE LYMPHOBLASTIC-LEUKEMIA;    EMBRYONIC STEM-CELLS;    LUNG-CANCER;    CHROMOSOMAL BREAKPOINT;    MALIGNANT-MELANOMA;    ADAPTER PROTEINS;    ARRAY CGH;    GENES;    GENOME;    AMPLIFICATION;   

DOI  :  10.1038/nature08822

来源: SCIE

【 摘 要 】

A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across several cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions. Several gene families are enriched among these regions of focal SCNA, including the BCL2 family of apoptosis regulators and the NF-kappa B pathway. We show that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival. Finally, we demonstrate that a large majority of SCNAs identified in individual cancer types are present in several cancer types.

【 授权许可】

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